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Various Types of Eukaryotic Intermediate Filaments

Intermediate filaments are cytoskeleton proteins that are approximately 10 nm in diameter and made of two parallel helices. They are stable components of the eukaryotic cytoskeleton. Along with microfilaments they bear tension to maintain the cell's shape, but they also organize the interior of the cell by anchoring organelles, are integrated into the structure of the nuclear envelope, and participating in cell junctions. Different types of intermediate filaments are present in different types of cells and structures.
Keratin, Lamin, Neurofilaments, Vimentins
Keratin
Entered/Authored by Alicia Prater Modified Saturday, 01 March 2008 11:08

Description: Keratins are proteins found in skin, nails, horn, claws, and hair. They offer a strong structure and protection for the cells. Keratin is an intermediate filament, consisting of two parallel helices. They are known to contain a lot of the amino acid glycine.

Lamin
Entered/Authored by Alicia Prater Modified Saturday, 01 March 2008 11:07

Description: Lamin is a cytoskeleton protein that provides structural support to the inner lining of the nuclear envelope within cells. As an intermediate filament it consists of two parallel helices.

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Neurofilaments
Entered/Authored by Alicia Prater Modified Saturday, 01 March 2008 11:07

Description: Neurofilaments are class III and IV intermediate filaments found specifically in neurons. Class IV filaments are found in heteropolymers of the three subunit types NF-L, NF-M, and NF-H. They were originally designated based on their separation on SDS-PAGE

Vimentins
Entered/Authored by Alicia Prater Modified Saturday, 01 March 2008 11:07

Description: Vimentins are cytoskeletal proteins involved in cellular structural support offering flexibility to a cell. They are a class III intermediate filament subunit in developing neurons. They are also found attached to the nucleus, endoplasmic reticulum, and mitochondria positioning and anchoring them in the cytoplasm.

 
 
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